Currently, there are 14 drugs in late-stage development across eight major markets. Sepsis, a condition caused by an abnormal ...

Atrial mechanical function was assessed by transmitral inflow. Soluble thrombomodulin and von Willebrand factor concentrations (both as indices of endothelial damage or dysfunction) and fibrin D-dimer ...

No drug specifically targets the underlying pathophysiological processes that cause sepsis and only symptomatic treatments ...

A recent clinical trial published in the Journal of American Medical Association revealed that the drug iloprost, commonly ...

Notable failures include AM Pharma’s ReCAP and Asahi Kasei’s thrombomodulin alfa trials. Tannen reflected: “There is a big unmet need for drugs that specifically target sepsis, as currently only ...

Design Retrospective analysis of the nationwide survey for recombinant human soluble thrombomodulin. Setting General emergency and critical care centres in secondary and tertiary care hospitals.

Biochemical and genetic approaches allowed us to identify two proteins on the endothelial blood vessel lining, thrombomodulin and the endothelial cell protein C receptor, that are critical to ...

In light of these concepts, current massive transfusion protocols incorporate hemostasis-directed resuscitation, or the pre-emptive administration of blood coagulation products along with packed ...

Thrombin generation was measured using 0, 1 and 5 pM tissue factor (TF) triggers. Active site-inhibited factor VIIa (ASIS) and recombinant thrombomodulin were added to study the contact activation ...

This study explores how endothelial cells maintain the pulmonary barrier and how its integrity is compromised in acute lung ...

Purpose Published evidence on the incidence and predictors of venous thromboembolism (VTE) in patients with cirrhosis of the liver is reviewed. Summary The frequently observed phenomenon of ...

Simvastatin restored the level of platelet aggregation to normal levels. Simvastatin enhanced the expression of CD39 and thrombomodulin mRNA initially reduced by IL-17 and TNF-α combination.