During PINK1- and Parkin-mediated mitophagy, autophagy adaptors are recruited to damaged mitochondria to promote their selective degradation. Autophagy adaptors such as optineurin (OPTN) and NDP52 ...
A collaborative study has uncovered that astrocytes, through autophagy, can effectively clear amyloid-beta proteins in Alzheimer’s disease, presenting a novel therapeutic target that departs from ...
Autophagy has been shown to play an important role in the immune ... Protein concentration was then detected using a BCA (bicinchoninic acid) protein assay kit. SDS-PAGE was conducted, and the protein ...
Aging diminishes autophagy in short-lived model organisms. This study uncouples macroautophagy and mitophagy in the aging mouse brain at the single-cell level in vivo by profiling two optical reporter ...
The triad interaction of ULK1, ATG13, and FIP200 is required for ULK complex formation and autophagy
Importantly, they identified a direct interaction between ULK1 and FIP200, which is crucial for autophagy. However, some aspects of this manuscript require further clarification, validation, and ...
Autophagy is an intracellular degradation process that works ... 50 µL media from each well was transferred to a new 96 well plate, and 50 µL LDH Assay Buffer was added to each well containing the ...
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