The symptoms of amyloidosis start subtly and will vary depending on where amyloid proteins collect. Symptoms might include: Skin changes, including a waxy thickening, bruising on the chest, face, and eyelids, and purple patches around the eyes

Amyloidosis that affects the skin is called cutaneous amyloidosis. It causes amyloid proteins to be deposited in the two layers of skin (the dermis and epidermis). It is considered localized amyloidosis because it mainly affects the skin and does not invade the organs.

Primary localized cutaneous amyloidosis (PLCA) is a condition in which clumps of abnormal proteins called amyloids build up in the skin, specifically in the wave-like projections (dermal papillae) between the top two layers of skin (the dermis and the epidermis). The primary feature of PLCA is patches of skin with abnormal texture or color.

PLCA occurs when amyloid proteins build up into clusters called dermal papillae between the top two layers of the skin, the epidermis and dermis. This accumulation can cause patches of skin to look or feel unusual, though skin symptoms vary depending on the type of PLCA a person has.