- Small strokes are the most common cause of white spots on a brain MRI. Blockages of small blood vessels can cause small strokes due to high blood pressure or diabetes. Large strokes are usually caused by heart disease or carotid artery disease. Sometimes, white spots are caused by silent strokes —small strokes that don't cause symptoms.www.verywellhealth.com/what-are-these-spots-on-my-mri-2488902
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