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  1. Nature
    https://www.nature.com › articles

    CREB and the CRTC co-activators: sensors for …

    • •Cyclic AMP-responsive element-binding protein (CREB) mediates induction of cAMP-responsive genes following its phosphorylation at Ser133 by protein kinase A (PKA). CREB phosphorylation increases i… See more

    Abstract

    The cyclic AMP-responsive element-binding protein (CREB) is phosphorylated in response to a wide variety of signals, yet target gene transcription is only increased in a subset … See more

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    Phosphorylation provides a rapid but reversible mechanism by which extracellular signals … See more

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    Acknowledgements

    We acknowledge support from the US National Institutes of Health, the Clayton Foundation for Medical Research, The Helmsley Foundation and the Kieckhefer Foundation.… See more

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    Authors and Affiliations
    Sanford-Burnham Medical Research Institute at Lake Nona, 6400 Sanger Road, Orlando, 32827, Florida, USA Judith Y. Altarejos Pe… See more

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  1. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    cAMP Response Element-Binding Protein (CREB): A Possible …

     
  2. People also ask
    Is CREB a cAMP regulated transcriptional co-activator?
    Recent studies indicate that CREB functions in concert with a family of latent cytoplasmic co-activators called cAMP-regulated transcriptional co-activators (CRTCs), which are activated through dephosphorylation.

    CREB and the CRTC co-activators: sensors for hormonal and ... - Nature

    nature.com
    How does a signal activate a CREB protein?
    A generalized sequence of events is summarized as follows: A signal arrives at the cell surface, activates the corresponding receptor, which leads to the production of a second messenger such as cAMP or Ca 2+, which in turn activates a protein kinase. This protein kinase translocates to the cell nucleus, where it activates a CREB protein.

    CREB - Wikipedia

    en.wikipedia.org
    How does CREB phosphorylation increase its activity?
    CREB phosphorylation increases its activity by promoting an association with the co-activator paralogues CREB-binding protein (CBP) and p300. The cAMP-regulated transcriptional co-activators (CRTCs) mediate CREB target gene activation following their dephosphorylation and nuclear translocation, when they bind to CREB over relevant promoters.

    CREB and the CRTC co-activators: sensors for hormonal and ... - Nature

    nature.com
    Is CREB binding protein sufficient for gene activation?
    Cardinaux JR, et al. Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. Mol Cell Biol. 2000;20:1546–1552. [ PMC free article] [ PubMed] [ Google Scholar] 50. Best JL, et al. Identification of small-molecule antagonists that inhibit an activator:coactivator interaction. Proc Natl Acad Sci USA. 2004;101:17622–17627.

    CREB and the CRTC co-activators: sensors for hormonal and

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  3. Wikipedia
    https://en.wikipedia.org › wiki › CREB

    CREB - Wikipedia

  4. Springer
    https://link.springer.com › article

    What turns CREB on? And off? And why does it matter?

    WEBApr 28, 2020 · This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and …

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  6. Wikipedia
    https://en.wikipedia.org › wiki › CREB-binding_protein

    CREB-binding protein - Wikipedia

  7. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    CREB and the CRTC co-activators: sensors for hormonal and …

  8. Cell Press
    https://www.cell.com › AJHG › fulltext

    Function and Regulation of CREB Family Transcription Factors in …

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    The Role of the Transcription Factor CREB in Immune Function

  10. ScienceDirect
    https://www.sciencedirect.com › science › article › pii

    CREB: A multifaceted transcriptional regulator of neural and …

  11. Cell Press
    https://www.cell.com › neuron › fulltext

    CREB: A Major Mediator of Neuronal Neurotrophin …

    WEBIn PC12 cells, neurotrophins transactivate cyclic AMP response element-binding protein (CREB) by inducing its phosphorylation on a critical residue (Ser-133) that enables CREB to mediate gene expression cooperatively …

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