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  1. Hereditary haemochromatosis
    Hereditary haemochromatosisGenetic disorder
    PrognosisSymptomsCausesDiagnosisTreatmentsClinical trialsRisk factors
     
  2. Radiopaedia
    https://radiopaedia.org › articles › haemochromatosis

    Hemochromatosis | Radiology Reference Article

    • Hemochromatosis is an iron overload disorder that affects the liver and other organs. MRI is the most sensitive modality to detect and quantify liver iron deposition, using T2* susceptibility artifact and gr… See more

    Epidemiology

    Hemochromatosis may be primary which is a genetic disorder or secondary which can result from a variety of diseases. Primary hemochromatosis is primarily (90%) due to an abnorma… See more

    Radiopaedia
    Clinical Presentation

    As hemochromatosis may affect a number of organ systems, patients not surprisingly may … See more

    Radiopaedia
    Pathology

    The fundamental pathology that underlies hemochromatosis is the accumulation of iron and an increase in total body iron stores (as high as 50-60 g) and abnormal non-reticulo… See more

    Radiopaedia
    Radiographic Features

    General visceral features of hemochromatosis are increased organ density (CT) and reduced organ signal intensity (MRI). Secondary imaging features include hep… See more

    Radiopaedia
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    Table of Contents
    Epidemiology
    Clinical Presentation
    Pathology
    Radiographic Features
     
  1. Magnetic resonance (MR) imaging is the most sensitive and specific imaging modality in the diagnosis of hemochromatosis. The susceptibility effect caused by the accumulation of iron leads to signal loss in the affected tissues, particularly with the T2 * -weighted sequences, which makes the diagnosis of iron overload possible.

    MR Imaging Findings of Iron Overload | RadioGraphics

    pubs.rsna.org/doi/full/10.1148/rg.296095511
    pubs.rsna.org/doi/full/10.1148/rg.296095511
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  2. People also ask
    What is hemochromatosis?
    Hemochromatosis is an iron overload disorder characterized by a progressive increase in total body iron stores and deposition of iron in some non- reticuloendothelial system (RES) body organs which results in some instances of organ dysfunction.

    Hemochromatosis | Radiology Reference Article - Radiopaedia.org

    radiopaedia.org
    Can MRI detect hemochromatosis?
    See the sub-article on MRI liver iron quantification. MRI is not only the most sensitive imaging modality for the diagnosis of hemochromatosis but is also able to estimate iron concentration within the liver, thus forestalling the need for repeated biopsies 6. Visceral iron results in susceptibility artifact which leads to T2* signal loss.

    Hemochromatosis | Radiology Reference Article - Radiopaedia.org

    radiopaedia.org
    What are secondary imaging features of haemochromatosis?
    Secondary imaging features include hepatomegaly, cirrhosis and signs of heart failure. The pattern of iron deposition is important. Predominant involvement of the liver, without deposition in spleen or bone marrow, is consistent with non-RES iron deposition and is characteristic of primary haemochromatosis.

    Haemochromatosis | Radiology Reference Article | Radiopaedia.org

    radiopaedia.org
    How is hemochromatosis diagnosed?
    Magnetic resonance (MR) imaging is the most sensitive and specific imaging modality in the diagnosis of hemochromatosis. The susceptibility effect caused by the accumulation of iron leads to signal loss in the affected tissues, particularly with the T2 * -weighted sequences, which makes the diagnosis of iron overload possible.

    MR Imaging Findings of Iron Overload | RadioGraphics

    pubs.rsna.org
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  3. RSNA Publications Online
    https://pubs.rsna.org › doi › full

    MR Imaging Findings of Iron Overload | RadioGraphics

     
  4. Radiopaedia
    https://radiopaedia.org › articles › haemochromatosis

    Haemochromatosis | Radiology Reference Article - Radiopaedia.org

  5. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Practical guide to quantification of hepatic iron with MRI

  6. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › pmc › articles

    Different forms of iron accumulation in the liver on MRI

  8. Radiology Key
    https://radiologykey.com

    Hemochromatosis - Radiology Key

    WEBNov 16, 2016 · Relatively common and underdiagnosed cause of liver disease. Affects 1 in 220 of some European groups. Clinical: Cirrhosis and “bronze diabetes”. Progressive injury of heart, liver, and pancreas. …

  9. National Center for Biotechnology Information
    https://www.ncbi.nlm.nih.gov › books

    Hemochromatosis - StatPearls - NCBI Bookshelf

    WEBMar 31, 2023 · Hemochromatosis is a disorder that causes excess iron deposition and, in turn, multiple organ dysfunction. Organs affected by hemochromatosis include the liver, pancreas, heart, thyroid, joints, skin, …

  10. UpToDate
    https://www.uptodate.com › contents › hereditary...

    Patient education: Hereditary hemochromatosis (Beyond the Basics)

  11. Radiopaedia
    https://radiopaedia.org › articles

    Haemochromatosis (skeletal manifestations) | Radiology …

  12. UpToDate
    https://www.uptodate.com › contents › clinical...

    Clinical manifestations and diagnosis of hereditary …