the net result is metabolic alkalosis with hypochloraemia and hypokalaemia, often with an expanded ECF volume Cushing’s Syndrome the excess corticosteroids have some mineralocorticoid effects and because of this can produce a metabolic alkalosis the alkalosis is most severe with the syndrome of ectopic ACTH production

Elevated cortisol levels cause increased sodium reabsorption, hypokalemia, and metabolic alkalosis. Cushing syndrome-related findings include the following: Obesity Swollen, round, puffy face (moon face) Accumulated fat on the back of the neck and between shoulder blades (buffalo hump) Excessive hair growth (hirsutism)