Naproxen and ibuprofen are both nonsteroidal anti-inflammatory drugs (NSAIDs) used for pain. The main difference is that naproxen (Aleve) is longer lasting, while ibuprofen (Advil or Motrin) provides faster pain relief. Both naproxen and ibuprofen can be used for various types of pain, whether from arthritis, menstrual cramps, or muscle strains.

Although ibuprofen and naproxen are very similar, they aren’t exactly the same. For example, pain relief from ibuprofen doesn’t last as long as pain relief from naproxen. That means you don’t have to take naproxen as often as you would ibuprofen. This difference may make naproxen a better option for treating pain from chronic conditions.

Ibuprofen typically will provide pain relief faster. Both drugs are similar in strength once they start working, and they have similar side effects, though Naproxen's effects can be expected to last longer. Keep in mind that you should not take both at the same time.

Naproxen (Aleve) and ibuprofen (Advil, Motrin) are both nonsteroidal anti-inflammatory drugs (NSAIDs) available without a prescription. They're often used to ease pain and reduce swelling. Naproxen lasts longer in your body, but ibuprofen is gentler on your stomach.

Naproxen (Aleve) and ibuprofen (Advil, Motrin) are both non-steroidal anti-inflammatory drugs (NSAIDs) that are available over-the-counter (OTC). They’re commonly used for pain and inflammation. The key differences between the two medications are that naproxen lasts longer in the body, and Ibuprofen is safer for your stomach.