A coiled coil is a structural motif in proteins in which 2–7 alpha-helices are coiled together like the strands of a rope. (Dimers and trimers are the most common types.) They have been found in roughly 5-10% of proteins and … 詳細

The possibility of coiled coils for α-keratin was initially somewhat controversial. Linus Pauling and Francis Crick independently came to the conclusion that this was possible at about the same time. In the summer of … 詳細

Coiled coils usually contain a repeated pattern, hxxhcxc, of hydrophobic (h) and charged (c) amino-acid residues, referred to as a heptad repeat. The positions in the heptad repeat are usually labeled abcdefg, where a and d are the hydrophobic positions, often being … 詳細

As coiled-coil domains are common among a significant amount of proteins in a wide variety of protein families, they help proteins fulfill various functions in the cell. Their primary feature is to facilitate protein-protein interaction and keep proteins or domains … 詳細

The general problem of deciding on the folded structure of a protein when given the amino acid sequence (the so-called protein folding problem) has only been solved partially. However, the coiled coil is one of a relatively small number of folding motifs for which the … 詳細

Coiled-coil motifs have been experimented on as possible building block for nanostructures, in part because of their simple design and wide range of function based primarily on facilitating protein-protein interaction. Simple guidelines for de novo synthesis of … 詳細

• Crick FH (1953). "The Packing of α-Helices: Simple Coiled-Coils". Acta Crystallogr. 6 (8): 689–697. Bibcode:1953AcCry...6..689C. doi:10.1107/S0365110X53001964.
• Nishikawa K, Scheraga HA (1976). "Geometrical criteria for formation of … 詳細