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  2. Systemic sclerosis is also called scleroderma, progressive systemic sclerosis, or CREST syndrome. “CREST” stands for: CREST syndrome is a limited form of the disorder. SS may only affect the skin in the early stages of the disease. You may notice your skin thickening and shiny areas developing around your mouth, nose, fingers, and other bony areas.

    www.healthline.com/health/scleroderma
    Systemic sclerosis varies in severity and progression, ranging from generalized skin thickening with rapidly progressive and often fatal visceral involvement (diffuse systemic sclerosis) to isolated skin involvement (often just the fingers and face) and slow progression (often several decades) before visceral disease develops.
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