Zebrafish is becoming a powerful vertebrate model for in vivo genetic studies of human development [1–3]. Zebrafish and mammals share similar blood cells and use common molecular pathways to regulate the production of blood cells including thymocytes [4–6]. In zebrafish, the first definitive HSCs de...

For use in genetic studies as an animal model, zebrafish was initially introduced by Streisinger and colleagues1 in the early 1980s. Large-scale N-ethyl-N-nitrosourea (ENU) mutagenesis was conducted in combination with extensive phenotypic screening2,3. Further phenotypic characterization of these E...

Understanding the detailed mechanism behind every human disease, disorder, defect, and deficiency is a daunting task concerning the clinical diagnostic tools for patients. Hence, a closely resembling living or simulated model is of paramount interest for the development and testing of a probable nov...

The Zebrafish Model Organism Database (ZFIN; http://zfin.org) is the central resource for genetic and genomic data from zebrafish (Danio rerio) research. ZFIN staff curate detailed information about genes, mutants, genotypes, reporter lines, sequences, constructs, antibodies, knockdown reagents, exp...